Which Method for Diagnosing Small Fiber Neuropathy?

Which test for diagnosing early human diabetic neuropathy?

Epidemiological studies show that diabetic neuropathy can affect 50–90% of patients with diabetes. Diabetes increases the risk of foot ulceration and amputation more than 23fold (1), and neuropathy is the major contributory factor to this increased risk. Neuropathy presents as painful neuropathy in;20% of patients (2), and it independently predicts all-cause and diabetes-related mortality (3). ...

Chapter 7 Small fiber neuropathy in sarcoidosis

Sjögren Syndrome-Associated Small Fiber Neuropathy

We conducted the current study to analyze the clinical, immunologic, and neurophysiologic features of primary Sjögren syndrome (pSS)-associated sensory small fiber neuropathies (SFNs). Forty consecutive pSS patients with SFN were included. SFN was defined by the presence of suggestive sensory painful symptoms with normal nerve conduction studies and abnormal neurophysiologic tests for small ner...

Small fiber neuropathy: A burning problem.

Small fiber neuropathy is increasingly being recognized as a major cause of painful burning sensations in the feet, especially in the elderly. Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. Diabetes mellitus is the most common identifiable cause of small fiber neuropathy, and impaired oral glucose tolerance and individual...

Small-fiber neuropathy: answering the burning questions.

Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a myste...